In this educational program, we will aim to help primary care clinicians better evaluate the potential for multi-cancer early detection screening to improve identification of cancer earlier in the disease course. Specifically, we will help clinicians analyze the accuracy of multi-cancer early detection technologies within the context of ongoing trials and choose appropriate patient populations who may be candidates for screening with these tests. Additionally, we aim to ensure clinicians are prepared for more mainstream screening with these tests, while being ready to discuss the meaning of test results with patients.